Two Harvard stem-cell scientists are teaming up with a German biotech company to expand the search for a cure for Lou Gehrig's Disease.
Harvard University professors Kevin Eggan and Lee Rubin will conduct amyotrophic lateral sclerosis trials in partnership with Evotec, the university and the company announced.
"We're not a pharmacy company and they're set up for this," said Harvard science spokesman B.D. Colen. "We are doing some of that already, but they're able to do it on a much larger scale."
ALS destroys nerve cells in the brain and the spinal cord, eventually leading to paralysis and death. There is currently no known cure or treatment that halts or reverses ALS, although several drugs in clinical trials hold promise.
The new amyotrophic lateral sclerosis trials will expand on Eggan and Rubin's brain motor neuron research and is the university's fourth collaboration with Evotec. The company is led by the former student of another Harvard researcher whose hormone treatment of diabetes sparked an earlier Evotec deal, said Colen.
Eggan, the first researcher to link the deterioration of motor neurons with the onset of ALS, is known for his development of a revolutionary use of stem cells in research that spares patients the danger of taking experimental drugs across the spectrum of human disease, Colen said.
"It literally moves the disease out of the patient and into a lab dish so then you can use it to screen for possible drug treatments," Colen said,
The finances for the ALS deal are confidential, Colen said. "But if ... down the road this does prove successful and it becomes a drug, there will be revenue coming back to the discoverers and to the university."
Efforts by former Gov. Paul Cellucci to fight the debilitating disease that claimed his life did not contribute directly to Rubin and Eggan's research, Colen said, "But in terms of making Massachusetts a hospitable environment to do this kind of research, absolutely."
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